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They include apolipoprotein E ( APOE ) (Liu et al., 2017), HMGCR ( vitamin D receptor ( VDR ) (Ovesjo et al., 2016), serotonin receptors HTR3B and HTR7 (Ruano et al., 2007), chloride channel protein 1 ( CLCN1 ) (Neroldova et al., 2016), eyes shut homolog ( EYS ) (Isackson et al., 2011
Mechanisms of receptor-mediated transcytosis at the blood-brain barrier
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For example, Janus-type MNMs have structural asymmetry, and traditional sputtering processes for the asymmetric coating of Janus particles often lead to incomplete coverage or excessive accumulation owing to uneven plasma distribution, resulting in low yields and large batch variations [281, 282]
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